Hi, I'm currently taking Linzess 290mg and at first I would get severe stomach aches, so I thought to myself no way am I taking this every day, so I started taking it every 3 days. BIG mistake. The stomach pains came worse. Now I've been taking it every day and at first yes I had stomach cramps due to my intestines moving but it started being more effective now that I'm taking it every day. I have had bowel movements every day instead of being backed up and miserable. I did find that taking this pill is better than taking laxatives or miralax.