Gleason 9 SO wants me to stop ADT @6 Mos for look see
My SO wants to stop ADT after 6 months and wait 2 months then test to see if PSA rises? Does this make sense? Just finished 3 mos of Lupron and switching to Orgovyx for a total 6-month ADT and had my 3 month visit with SO Thursday.
T is 3, PSA is below 0.014 considered UD.
Gl-9 Gr-5 Crib-3,4,5 RP 2.5 years ago, BCR 2.22 at 2 years followed with Neg PSMA Pet 4 mos. ago and 25 EBRT salvage due to
Suspected (no scan light ups) Prostate bed "Klingons". No known spread to lymph system.
I am a retired tradesman not a scientist.
I will be getting a second opinion next week from a local NCI Comprehensive Cancer Center.
Does anyone have experience with this category and treatment? Does it make sense based on your personal experience and treatment regimen?
Thanks for your thought's fellow warriors.
Interested in more discussions like this? Go to the Prostate Cancer Support Group.
Thank you for the information and your experience. I’m 72, my brother died from PC at 62, just 6 months after diagnosis (2006). My sister died from pancreatic cancer at 74, and my other sister is now fighting breast cancer; BRCA 2 had not been kind to my family.
I will signup for the bimonthly meetings you mentioned.
Thanks again and take care.
My Gleason was 8. I had 42 sessions of IMRT four years ago. I quit ADT after one year due to joint pain. My urologist wanted me to stay on it for 1 1/2 to 3 years. Since before I quit ADT, I have been taking Turkey Tail tea daily. Research has shown that the polysaccharides in Turkey Tail tea can kill prostate cancer stem cells which reduces the chance of metastasis. My recent PSA is 0.07. We all need to own and take personal responsibility for our own treatment of prostate cancer. I wish you the best. https://pubmed.ncbi.nlm.nih.gov/37368660/
With Gleason 9, I suspect they'd treat it as aggressive regardless of Decipher score. I *think* Decipher is most useful for borderline results like Gleason 7, but I'm just a layperson.
Hi,
The clinical trial schema(below) uses a set of risk indicators. One risk => low risk group (radiation only), two or more risks => moderate risk group (radiation + ADT). DECIPHER score >.85 is counted as high risk - mine was .32. That put me in the low risk group of the high risk prostate cancer ADT study.
I have been told that DECIPHER has been shown to be very accurate, and is now part of their standard risk analysis.
Group I: Low Risk
Decipher Genetic Score < 0.85 and
1 High Risk Factor (Gleason 8-10, T3, PSA >20)
Dose: 35Gy/ 5 fx (RBE), 60Gy/ 20 fx (RBE), 70 Gy/28 fx (RBE)
No Androgen suppression (AS).
But I would not be surprised if different groups or oncologists gave it different weighting in their analysis.
I'm rethinking my original post in this thread (I think it was the second post). I'm not upset that my urologist took me off ADT for awhile. What bothers me is that he waited until my PSA had gone way up before putting me back on ADT, but even worse, I asked him on several occasions if I should be seeing an oncologist, and he strongly discouraged that. This was before I had Medicare, so trying to make an appointment with another doctor without a referral was difficult.
I finally talked him into letting me have a PSMA, which cost me $3,000 out of pocket.
Sounds like a private urology practice like I am leaving. They claim to be the largest in town, but nowhere do I hear them saying they are the best. You need to be lucky or know someone in there that is bonified good. I am still on private insurance and can choose providers. Medicare is just around the corner.
I hope all works out for you.
I am stopping my Dr. and not planning on stopping ADT for a year or two. Wondering if nmHSPC is a fancy way of saying pre-mHRPC purveying false hope.