I had stage 1B triple positive breast cancer in 2022 with two invasive masses. I had a lumpectomy, chemo with Herceptin, then 25 doses of radiation. Then I had a mastectomy with immediate DIEP FLAP reconstruction. Completed Herceptin infusion. And take tamoxifen. My first CA 27.29 was 28.39 and I joked with my oncologist that it should be lower since I just finished treatment (or so I thought). She explained that it would fluctuate and the inflammation and infection can affect the results. Every 3 months my count went down, little, by little. Until two years later it was 13.28. Then, this time it shot up to 24.68. Mine has never gone up. It has always gone down. I know it’s not over 38, or as high as most of yours, but what the heck? Also, since chemo, I’ve lost 65 lbs, w/o trying to, my lymph nodes are always swollen. Radiology has biopsied two that were benign. I’m trying not to freak out. My oncologist is on maternity leave. I don’t know the doc who is covering for her, so that feels awkward… I did call oncology and the nurse of course said that she would get back to me….that was a week ago. Should I continue to pursue this or wait on them to follow up since it’s not over 38?