Hi Jef : ),
What I found in papers is that it is more about formation and type of cribriform glands. If the pattern presents as "poorly formed / fused glands" it is LESS aggressive than "large , irregular cribriform glands. The term of "poorly formed / fused glands" was exact wording in biopsy report and I could not believe my eyes- had to re read it about 10 times to make sure I am really seeing what I was seeing . I read about 50 articles about cribriform and IDC and this was the only one that went into such detail and it is the newest one (2024 , Urologic Oncology), I had to pay for it but it was worth it. In different article I found out that IDC also has 2 types : so called 1 and 2 type.. IDC 1 has almost the same predictions as non IDC. IDC-1 has loose cribriform present and IDC2 solid and dense cribriform. I mean , I am holding onto straws here, I know, but a straw is better than nothing ; ).