I've had sensory, motor, and autonomic neuropathies since 2011. I took a multivitamin with a high amount of B6 for several years. At the end of 2023, I began taking B complex, and beginning in early 2024, I had a significant, impactful flare-up that lasted throughout the year. I also started losing handfuls of hair. In October, I learned about B6 toxicity and asked to have my nutrients tested, and I was high in B6. I stopped taking the two supplements, and now I am moving back towards what I consider a typical plateau for my neuropathy symptoms; my hair loss isn't as severe, and B6 serum levels are going down slowly. It can take years for the B6 stored in nerves and muscles to move out of the body. And yes, exercise and lots of fluids help the process. Now I only take the individual vitamins and minerals that testing shows I am deficient in. Even a supplement with only 4mg of B6 is too much! We get more B6 than we need from our diet. But, there can be other reasons for elevated B6. I suggest asking for an intracellular nutrient test, as blood serum is not always enough. I will do this very soon because my blood serum B12 is still very high without supplementation, and it IS water soluble, unlike B6. https://www.spectracell.com/blog/posts/serum-vs-intracellular