I had radical nephrectomy last year. I have tons of arthritis. I went on keytruda every six weeks for 8 sessions when they stopped the infusions. No sign of cancer. My only side effect from infusions was I got very tired for about two weeks after the first few infusions. Then it went away. I never had joint pain and I can tell you I have arthritis in my knees, shoulders and especially back. But everyone is different so just keep monitoring your pain and keep doctors well informed of all your symptoms. They should know what to do. Good luck my fellow afflicted friend.