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Asymptomatic MAC patient here, on the big three for one year now. . . . . chest xrays and CT scans show no changes, doctor says my images will always show battle scars . . . . .so my question is. . . . how will they know when i can stop the drugs, how will they see changes or improvement. I have no sputum to culture. If i stop the antibiotics, will i progress to BE? I do have lung nodules.

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Replies to "Asymptomatic MAC patient here, on the big three for one year now. . . . ...."

It's so hard when there are so many questions. If you don't produce sputum, are they likely to do a bronchoscopy, and stop the treatment if your cultures are negative? It's great that it is not progressing and scans remain the same!

It is my understanding after seeing Dr. Pamela McShane in Texas (before she moved to a position with NIH in Wash DC); that you need 2 negative sputum samples in a row, then in my case, she recommended I continue the Big 3 AND nebulized Arikayce for another year. Everyone's anatomy is different. MAC is VERY slow growing & slow to culture. If you have no sputum, she recommends nebulizing with 7% hypertonic saline/airway clearance to get sputum out, & if still no sputum, possibly need to ask about a bronchoscopy to check status in lungs & get sputum samples. Just my opinion. I've been on the big 3 for 11 months & Arikayce nebulized since March 7, 2025. Best wishes to you !