← Return to Gleason score 3+4 plus perineural invasion

Discussion

Gleason score 3+4 plus perineural invasion

Prostate Cancer | Last Active: 5 days ago | Replies (16)
Comment receiving replies
@heavyphil

Hey bud, I too had extensive PI - figured I was a goner.
But my RO at Sloan actually co-authored a study on PI and the conclusion, very roughly expressed, was that it was a measure of how far laterally (and extensive) the cells have spread and NOT a measure of aggression.
Of course, lateral expansion implies capsular encroachment so that’s not a good thing either.
My surgical path showed a tiny break in the capsule, but margins and lymph were negative. Still, I just finished SRT so take every finding with a boulder of salt.
Phil

Jump to this post

Replies to "Hey bud, I too had extensive PI - figured I was a goner. But my RO..."
happydappy | @happydappy | 5 days ago

Thanks for sharing. I realize that nerve invasion does not necessarily equal metastasis but it means the cancer cells are not necessarily bundled in a tight lesion but connecting to other cell types. Lots of nerves in the prostate as those of us who've gotten biopsies can attest so they are prime targets for the cancer cells. I read one study that discussed the biochemistry behind nerve invasion.

So glad your margins and lymph nodes were clear! May you stay cancer free.

VIEW AND REPLY