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Gleason score 3+4 plus perineural invasion
Prostate Cancer | Last Active: 27 seconds ago | Replies (17)Comment receiving replies
Thanks for sharing that study website - I'll sign up.
The report noted nerve invasion (called perineural). The literature seems to be unclear about how common this is with some rates in the teens and others reported to be upwards of 70% of cases. There are a lot of nerves in and around the prostate. There also seems to be disagreement about how nerve invasion could impact spread in the prostate In other cancers, it's a common avenue of spread as the cancer cells readily travel along the nerves spreading to other body parts. This leads to disagreement on how important nerve invasion is for making treatment decisions in prostate cancer. Some say no big deal and others say it is. Seems like an area that needs more research. I'm interested to see what my doctor says when I have the first follow up after the biopsy report.
Replies to "Thanks for sharing that study website - I'll sign up. The report noted nerve invasion (called..."
Hey bud, I too had extensive PI - figured I was a goner.
But my RO at Sloan actually co-authored a study on PI and the conclusion, very roughly expressed, was that it was a measure of how far laterally (and extensive) the cells have spread and NOT a measure of aggression.
Of course, lateral expansion implies capsular encroachment so that’s not a good thing either.
My surgical path showed a tiny break in the capsule, but margins and lymph were negative. Still, I just finished SRT so take every finding with a boulder of salt.
Phil
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As I said in The previous message PNI is not considered a real problem by the doctor talking at the PCRI Conference two weeks ago. The Doctors that talk at These conferences really have a lot of experience. The Doctor said
“PNI and extra capillary extensions do not predict metastasis”
Essentially saying they don’t cause future problems somewhere else.