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Concern about Globulin-Predominant UPEP Proteinuria Pattern

Kidney & Bladder | Last Active: Apr 28 6:56pm | Replies (6)
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@cehunt57

@stlmark Welcome to Mayo Clinic Connect. I have CKD stage 4 (chronic kidney disease). I also have albuminurea (protein in the urine) that my nephrologist keeps a close eye on. Having said that, I am unfamiliar with the UPEP protein composition that you refer to. (It is all Greek to me, literally!) Hopefully another member who has some experience with this will respond soon. In the mean time, do you have a good working relationship with your nephrologist and do you trust this provider?

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Replies to "@stlmark Welcome to Mayo Clinic Connect. I have CKD stage 4 (chronic kidney disease). I also..."
stlmark | @stlmark | Apr 24 4:23pm

Thank you, Cheryl. I really appreciate your encouragement.

My nephrologist is confident that the protein composition in my urine isn’t concerning, but she did say it’s reasonable to get a second opinion if I’m still worried—which I am. My primary care provider is referring me to hematology, since the excess globulins in my urine could suggest overproduction of certain proteins. My SPEP came back normal, so I’m hoping hematology will still agree to evaluate me further.

I’ll update once I know more—thanks again for listening!

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