@james46
I can empathize with your symptoms and panic attacks. My experience taking anxiety/depression medications (almost 30 years off and on) has been that new medication should start to make you feel a little better after 2 weeks. If there are bad side effects early on, they usually do not get better with time or increased dosages.

Zoloft/sertraline has helped me with panic attacks and anxiety/depression combined with Wellbutrin/bupropion. It can take time and trial and error to find the right medication and if adding a combination drug can improve positive outcomes.