It may be early to know if the lower dose will provide lasting bone density. This paper states that while there was an increase in bone density on the lower dose it is unknown whether it will have lasting effect. It would be awesome if it does! The study was only for one year, though.

I think the current belief is that the higher dose, maybe even given in multiple lower dose sessions, is what is needed to give the 3-5 year (minimum) benefit. I don’t know if my insurance will pay for multiple lower doses because it is charged as a hospital visit - which is always incredibly expensive. Even if the infusion is given at a clinic or infusion center, those facilities usually bill like a hospital visit- something to do with the quality of care/facility that qualifies them as a “hospital”.

I’m going to ask my endocrinologist before this upcoming infusion. I did ask the cancer enter rheumatologist (who is co-provider for my bone issues) about delaying the third infusion and he stated that it needs to be given three years in a row.