I would just like to add that type of aggressiveness of PC can effect treatment choice.

My husband had one core with intraductal and cribriform present and even though his gleason score is 4+3 he should be treated as high risk case.
Some studies show that patients with intraductal cancer have better survival with initial RP regardless if later RT is needed or not. Also, I read on couple of other forums about cases where RT did not kill cribriform cells in prostate even with high precision radiation. Those cases could be aberrations but it is hard to know since only about 2% of PC have intraductal component. BUT, to be on a safe side, we will probably opt for RP - I say probably since we still did not have a chance to talk to any specialist and are still waiting for PSMA results so we do not even know if cancer left prostate or not.

I am just writing this as info. for new patients who are trying to decide between RP or RT to know that in some cases RP has advantage over radiation.