Hi! I went with a second lumpectomy and radiation. I am happy with the results, and so far, no indication of any cancer remaining. I am taking Anastrazole, and amazingly have had no serious side-effects. That said, everyone needs to decide for herself what course to take. I wanted to preserve my breast because my husband and I are still sexually active, and a mastectomy removes all nerves and nipple. (Forgive me for being so plain, but that was definitely a part of my decision.) If that is not a concern for you, a mastectomy could give you more peace of mind. I will say that the radiation was not painful or even that inconvenient (I only live 20 minutes away from the radiology office). The worst side effect has been dry, itchy skin, but once I found the right lotion, that has gotten better. Good luck, whichever path you choose!