The clinical trial drug is the same, and there's no way it's side effects have changed. What has changed is the new bottle of loperamide that I started 2 days ago. I still have to take lots of loperamide and lomotil, I just have to re-figure out how much. The labels that the pharmacist put on the two loperamide bottles are exactly the same. It is not the manufacturer's bottle or label. But the new loperamide has a much stronger effect, such that I can now control the problem with less than the maximum dose, whereas before even the maximum dose didn't"t control it.