@rascal, Although I do not want to be negative, I do have an altered view of the response. Here is a link to a pretty good explanation of all facets of this issue. I also know that there is a Mayo video interview that covers this topic, which I have seen on Connect and is available online. I would hate for anyone to purchase something for which there is no hope of helping with a serious medical issue. I got caught in this trap with the mess in CA last year and succumbed out of desperation. For me, there was absolutely no pain assistance from hemp oil in any shape, form, or quantity.