Hey neronel, I did not notice any changes other than the usual SE’s they warn you about - some diarrhea, fatigue, etc.
But recent bloodwork showed a profound change in my white blood cell count; it’s probably transitory but it is something to consider if you are already immuno-compromised.
If you go on ADT, also expect your red blood cells to be affected as well.
It’s a personal decision; I have zero regrets about having ADT or radiation. Best,
Phil