@lostintheworld Welcome to Mayo Clinic Connect.

Having treatment resistant depression can be so frustrating when we are honestly trying everything we can think of to overcome it! One of the things I have learned is that because everyone is different, even when our journeys seem the same, we read others' successes and hope it can be ours, too. All of us have tried so many paths to better thinking/coping.

Here is what Mayo Clinic has to say about ECT: https://www.mayoclinic.org/tests-procedures/electroconvulsive-therapy/about/pac-20393894.

I hope that @winnee has good things to report.
Ginger

I have TRD for over 50 years. In the 80s I found some good relief from Prozac that lasted me a couple of years and then the deep depression returned. I’ve been on most anti-depression drugs, trying other kinds of cures the one that were the best for me which was startling was ECT. I was truly amazed at the rapid at the rapid change in mood from one session. I had six more as I stayed in the hospital for treatment that was eight years ago. I’ve had a return of depression, but not so dark as it had been in the past. I’m back on SSRI s. Genuinely my mood is OK. I’m in my mid 70s now and have just stopped taking Prozac and started Cymbalta. I’ve never tried Cymbalta before so this should be interesting. Depression sucks!
I’d say try ECT again it was remarkable for me. A game changer..