I said I would report on my experience. My insurance did cover a one month supply and I an reaching the end of the month and for me...I stress I am a sample size of one, it helps but it took a while. That doesn't make sense based on the pharmacology but that is my experience. I still take Tylenol and Celebrex, as I had been. At the 3 week point I started to notice an improvement...I'm not running marathons but I went to party last weekend. I tried a 100mg dose for a few days at my pain doctor's suggestion and that was better but obviously not affordable. As of yet, no side effects, but no one knows side effect profile with long term use. My insurance company finally agreed to partially cover it for a year and it works well enough and i stress FOR ME that I will continue in spite of the expense. If you have no insurance at all Vertex may work with you. I hesitate to share this because it really has no relevance to others...this is just my experience. They always want numbers which is ridiculous but I would say the improvement is about 2 points. Just an FYI.