I don't know because I chose to do all three. I was diagnosed with ampulla of Vater adenocarcinoma in January of 2023, shortly before my 59th birthday. I did my own research and consulted with a specialist at City of Hope and based on what I was hearing I came to the conclusion that my best chance of long-term survival was to have the Whipple procedure performed as soon as possible. I managed to get the surgery done by the end of February 2023. I pushed for the earliest possible date. I had clean margins but significant lymph node involvement. After consulting with my doctors I decided to follow up immediately with chemo (12 rounds of folfirinox) and afterwards radiation. Chemo was awful, radiation not so bad, relatively. It took a year to complete my follow up therapies. It took a while after that before I started feeing myself again. My digestion will never be the same but it's not that bad, really. I started taking Creon to help with digestion. I was always health conscious and in pretty good shape before this happened so it came as quite the surprise. But I had a couple of situations in life that had me extremely stressed for a long time, which I think led up to the cancer. I made a number of changes to reduce my stress levels and now, both physically, and mentally, I feel fantastic. Follow up scans as recently as last weekend have so far been clear. I don't know if, when, or where the cancer will show up again but I am very happy I went through with the surgery, chemo, and radiation. Don't get me wrong. It totally sucked and I had some really hard times getting through it all. But for me, my wife, and my children it was totally worth it.