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@mayblin , I am so excited to share my CTX results from five days ago. My CTX result in May, 2024 was 688. The result today, April, 2025, was 138! That's about an 80% decrease! I began HRT (.25 Estrodiol patch and micronized Progesterone 100mg) in July of 2024 and have been taking Keith McCormick's recommended supplements since December of 2023. I mentioned previously that my REMS Echolight spine T score went from -3 in April 2024 to -2.6 in February 2025. I was hoping to at least stop the progression of loss, so this improvement was a bonus. My total hip Echolight T score went from -2.6 to -2.3. The Echolight shows my fracture risk to be on the border of low/moderate so reasonably good bone quality still. The next test will be another DEXA with TBS I am waiting for. My worst DEXA T score was spine -3.5 in November, 2023. I am hoping there will be some improvement on the DEXA as well and that the TBS shows reasonably good bone quality. It is so encouraging and empowering to get this CTX result without heavy medication.
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I’m happy for your success! Thank you for sharing your amazing results. Would you mind sharing which supplements McCormick suggested you take?
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This is awesome @debbie1956! The reduction in CTX is phenomenal. This paper published long time ago showed that a greater than ~55% reduction of CTX after 6mo estradiol patch is correlated with a positive bmd response at 2 years:
https://pubmed.ncbi.nlm.nih.gov/10831925/
Your ALP changes over time is interesting and confirming the information that we knew. Mine almost doubled from pre-tretament of Forteo to 13mo with Forteo. Yours went the other way. As you suggested, the reduction in your ALP could be indicative of a downturn in bone formation which is best confirmed by bone-specific ALP. Curious, were your other liver enzymes such as ALT, AST and total bilirubin all within normal range during the period you had 'abnormal' high ALP?
Your results also confirm that transdermal estradiol patches, even at a low dose, could suppress CTX to this level. Well, at least for both of us 🙂 . When I first saw my CTX result, I was thinking that I might have a low baseline (which I did not have) to start with. Now I don't really need to second guess estrogen's power. Thanks Debbie.