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The paradox of testosterone and ADT
Prostate Cancer | Last Active: Apr 10 10:22am | Replies (82)Comment receiving replies
"..I know what you are saying, Hans, but you positively KNOW in 30 days if your cancer is ADT sensitive. My T went from around 625 to 5 - FIVE! in one month."
So the T goes down fast, which makes complete sense.. And what about the the tumor response to the lowered T? Did your tumors shrink and PSa go down as well? That is the plan and hopefully your result. Its also the question I keep dancing with because of the Duke study on T slowing growth in advanced prostate cancer. Does the lowered T reduce the prostate cancer in all cases, or might it let the ca have a field day in some rare cases? Teting for androgen receptivity might help pre-ADT...so it seems.
Replies to ""..I know what you are saying, Hans, but you positively KNOW in 30 days if your..."
The size of the metastasis frequently do reduce, That’s one reason the radiation oncologist like to do ADT first. I’ve seen people post actual before and asked numbers in this forum and they were noticeable size differences. The PSA always goes down With ADT, whether it stays down is another thing. If it doesn’t stay down, people are called castrate resistant.
Yes, my PSA went from .18 to < .05 - And that was just one month. I would think that the PSA drop lags a bit behind the drop in T. Small numbers but the % change is dramatic.
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So my testosterone went down to .5 and PSA from 26.7 to 6.7. Yes, it went down but the fact that PSA didn’t drop further in the near total absence of testosterone, causes me to be concerned.