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The paradox of testosterone and ADT

Prostate Cancer | Last Active: Apr 26 11:59am | Replies (92)

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@heavyphil

I know what you are saying, Hans, but you positively KNOW in 30 days if your cancer is ADT sensitive.
My T went from around 625 to 5 - FIVE! in one month. If it did not, drs would have probably given it another month to see if it stayed the same, decreased or even increased. Only THEN would they have changed the regimen, which works 99.99% of the time.
Is 30-60 days an unreasonable amount of time in the greater scheme of things?
Do you feel that 30-60 days in the “wrong” direction irreversibly dooms you to treatment failure?
You and I have debated these points before and it all comes down to genetic testing, although I have never had it done myself.
Is there even a genetic test which shows ADT response and effectiveness? I don’t know but it doesn’t seem that it should be all that difficult.
And as for the questions posed by @dpfbanks, is it not possible that your husband’s pretty darned high T levels are a potent source of his cancer’s fuel? I mean 745 is robust to say the least and could be the obvious culprit hiding in plain sight, no?
Occam’s Razor tells us that the simplest theory is usually the correct one….
Phil

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Replies to "I know what you are saying, Hans, but you positively KNOW in 30 days if your..."

This is a good rule of thumb to live by....

"Occam’s Razor tells us that the simplest theory is usually the correct one…."

What I hear in other comments is the total disregard of the word "usually" in the phrase, like not even a possibility.

"..I know what you are saying, Hans, but you positively KNOW in 30 days if your cancer is ADT sensitive. My T went from around 625 to 5 - FIVE! in one month."

So the T goes down fast, which makes complete sense.. And what about the the tumor response to the lowered T? Did your tumors shrink and PSa go down as well? That is the plan and hopefully your result. Its also the question I keep dancing with because of the Duke study on T slowing growth in advanced prostate cancer. Does the lowered T reduce the prostate cancer in all cases, or might it let the ca have a field day in some rare cases? Teting for androgen receptivity might help pre-ADT...so it seems.