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The paradox of testosterone and ADT
Prostate Cancer | Last Active: Apr 10 10:22am | Replies (82)Comment receiving replies
So, then, what happens if your prostate tumor grew in a naturally low testosterone environment and hence learned how to draw nutrients from sources other than testosterone? That would make the treatment with ADT counterproductive, as it would entice the tumor to become even more aggressive. The questions I have: "How do you find out?", and "How do you deal with this?". all the while "dealing with the reality one is dealing with a dogma-driven oncologist"
Replies to "So, then, what happens if your prostate tumor grew in a naturally low testosterone environment and..."
From what I have read you can test biopsy tissue for 'androgen receptivity', which is my exact question - if you have biopsy tissue (like we do from a lung biopsy), why not test it for androgen receptivity, or WHEN do they test for it?
Sorry long Google search:https://www.google.com/search?q=testing+tumors+for+androgen+receptivity&sca_esv=edec2e4b4572a4c0&sxsrf=AHTn8zr4UnHkmgok-mBDwlf1R73vyw67Ng%3A1744147312205&ei=cJP1Z9KSDLK0ptQPp5rbiQE&ved=0ahUKEwjSiuuHr8mMAxUymokEHSfNNhEQ4dUDCBA&oq=testing+tumors+for+androgen+receptivity&gs_lp=Egxnd3Mtd2l6LXNlcnAiJ3Rlc3RpbmcgdHVtb3JzIGZvciBhbmRyb2dlbiByZWNlcHRpdml0eTIIEAAYgAQYogQyCBAAGIAEGKIEMggQABiABBiiBDIIEAAYgAQYogRIzERQxQRYtBFwAXgBkAEAmAGdAaABiAaqAQMyLjW4AQzIAQD4AQGYAgigArMGwgIKEAAYsAMY1gQYR8ICBxAjGLACGCfCAgUQABjvBcICCBAAGKIEGIkFwgIKECEYoAEYwwQYCpgDAIgGAZAGCJIHAzMuNaAHnx-yBwMyLjW4B6sG&sclient=gws-wiz-serp
So many people go from surgery to recurrence, It may happen in a few months or many years, but it almost every single case ADT will bring the cancer down to undetectable. We’re talking somebody that has had no cancer drugs for 17 years, His reoccurrence has occurred by having lots of testosterone right there, So taking the testosterone away, should stop the cancer.
I don’t know what you’re talking about when you say grow in a naturally low testosterone environment. The only way you get a low testosterone environment is you take a drug that cuts down the testosterone or you get an orichotomy. If the PSA rises with an ADT Drugs, then you have castrate resistance.
How is ADT counter productive If you become castrate resistant. I know in my case Lupron still kept my PSA low, After I became castrate resistant, So it did make sense to continue using it.
Maybe I have missed your point?
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I know what you are saying, Hans, but you positively KNOW in 30 days if your cancer is ADT sensitive.
My T went from around 625 to 5 - FIVE! in one month. If it did not, drs would have probably given it another month to see if it stayed the same, decreased or even increased. Only THEN would they have changed the regimen, which works 99.99% of the time.
Is 30-60 days an unreasonable amount of time in the greater scheme of things?
Do you feel that 30-60 days in the “wrong” direction irreversibly dooms you to treatment failure?
You and I have debated these points before and it all comes down to genetic testing, although I have never had it done myself.
Is there even a genetic test which shows ADT response and effectiveness? I don’t know but it doesn’t seem that it should be all that difficult.
And as for the questions posed by @dpfbanks, is it not possible that your husband’s pretty darned high T levels are a potent source of his cancer’s fuel? I mean 745 is robust to say the least and could be the obvious culprit hiding in plain sight, no?
Occam’s Razor tells us that the simplest theory is usually the correct one….
Phil