UCSF was an hour and a half away. My daughter and husband were going to stay with me throughout, alternating 12 hour shifts. They rented a studio on Air B & B, or VRBO. It was not that much more expensive than a hotel/motel, but of course, hotel rates in San Francisco are high. The plus was it had its own kitchen. Counting the day of the surgery, whereby I had to arrive at the hospital at 6:30 a.m., I was there for 3 days. (So just two days post surgery.) I was eager to get home. But I had a short road trip. I think if you are flying you should run it by your surgeon. Even before my surgery, I always felt pressure in my head on take-offs and landings and maybe the doctor would recommend a decongestant or something post surgery. You'll be on a lot of meds going home and I wouldn't make the decision on my own to mix a decongestant with the other meds. (In years past, my primary care doctor advised me to take a decongestant 45 minutes before take-off.) Maybe it would be better to stay another night or two at a hotel/VRBO just to make sure you're feeling fine if you are flying. I think I would prefer a road trip if the commute from the hospital is 5 hours or less.