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The paradox of testosterone and ADT
Prostate Cancer | Last Active: Apr 10 10:22am | Replies (82)Comment receiving replies
Seventeen years is a long time - anything can happen. But it’s not like your husband was on ADT all those years so why the castrate resistance?
True, it can happen all on its own but I’d be interested to see if the PSA drops - if and when- your husband is placed on ADT. If it does, he’s probably not castrate resistant.
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@heavyphil Thanks for the input and we are curious too. The eventual failure of ADT when the tumors become castrate resistant, along with side effects of ADT, urge us to question everything prior to swallowing the pills. What if the tumor seeds living in lung tissue all this time have mutated and are not reliant on testosterone? My hubs T has risen pretty significantly since the RARP (from 495 - 800) - is that coincidence, protective intention by the body? Why not test for androgen receptivity prior to ADT? I ask these questions here so those docs trying to care for my hub don’t show me the door!