Have never heard of ototoxic drugs. Very interesting. I didn't realize that a drug could affect your ears!!!! I have had two knee surgeries -- ten years apart. (The only surgeries I've had.) For the surgery last year, they gave me a spinal injection. But for the first one, ten years ago, they put me under. And I think that my hearing loss started around that time. It would be interesting to know what kind of medications they used.