I have long known about metformin’s “supposed” use as an anti/cancer agent. One of my own patients - a physician - treated his Gleason 6 with metformin, doxycycline and aspirin and it was downgraded to PIN on his next biopsy; this was over 7 yrs ago and he moved out of the area so I don’t know what ultimately happened.
I am certainly not against the use of orphan drugs because hey, you just never know…
But as one cancer researcher once told me, “cancer always finds a way”. If the genetic makeup of your cancer is very aggressive as in glioblastoma or neurendocrine (pancreatic) cancer you have a MUCH greater chance of dying, rather than surviving.
She told me that she had seen many aggressive cancers respond initially to immunotherapy, only to quickly overwhelm the drug and actually use it as food.
My best friend’s son had this exact experience - multiple metastases AFTER a course of immunotherapy.
BTW, his wife was a nutritionist and cut ALL sugar from his diet just days after his diagnosis. He was dead in 18 months.