Yes, the bisphosphonates preserve what bone you have and suppress bone remodeling. Our bones naturally develop microfractures that need to be repaired and its the development of these microfractures that prompts the osteoclasts to start the remodeling process. The osteoclasts signal the osteoblasts to come in to build new bone. This all stops on bisphosphonates but the wear and tear on your bones never stops.

I tried Tymlos then generic Forteo between June 2024 and March 2025. I had fatigue, bone and joint pain, constipation, bloating and a bit of nausea on both. Tymlos was a little easier while Forteo was awful.