What is HoLEP? Holmium laser enucleation of the prostate is a minimally invasive procedure that uses pulses of laser beam to remove tissue from the inside of the prostate, which surrounds the urethra (the tube leading from the bladder to the urinary opening). Google search says its to help with BPH. It doesnt sound like a procedure that would have done anything with the cancer. Probably why the PSA did not drop.