It was a transdermal cream from a compounding pharmacy. Estriol/Estradiol 50:50 0.3 mg per 0.5gm and Progesterone 25 mg per 0.5 gm both per two clicks from the container which you twist to dispense. Both could be applied vaginally or on the abdomen, inner thigh or inner arm. When I was out in California helping my daughter I first had a consultation with a naturopathic doctor who only prescribed the estrogen first to prevent any side effects. Then she was going to add in the progesterone. But I came back to Arkansas and had to see my regular doctor who said she had to prescribe both. I didn’t have any side effects with just the estrogen but boy, I sure did when I added in the progesterone. I started cramping just like I was going to have a period, with bloating, constipation and worse hot flashes so I had to stop. The problem was my regular doc didn’t have much experience with bioidentical hormones and couldn’t guide me and told me to call the compounding pharmacy which weren’t a lot of help except to say that I was on too low a dose but I was too scared to continue until I got back to “normal” I do still have my uterus and know I have to take the progesterone if I use the estrogen.