@sue417
When I was put back on Zoloft/sertraline, it was in January/February of this year (2025). I felt some improvement after the first few weeks on 25 mg and then was increased to 50 mg around the 4 week mark. I then started to feel the dark, heavy cloud start to lift and became hopeful that I might feel better and can find a little of myself again. After 8 weeks/2 months, I was then increased to 75 mg. I have been at this dose for about 3-4 weeks now. I feel okay but a little more tired so think I need to cut back dosages a bit for both Zoloft/sertraline and Wellbutrin/bupropion.

I remember being put on 25 mg sertraline when I was pregnant because I started to have panic attacks (may have been due to hormone changes). It started to work within a couple weeks. I think I was on that dosage for a year or two because I then struggled with postpartum depression for several years.

It is good to give new medication and dosage adjustments a couple weeks to a month to see how you are doing. If you get really bad side effects early on, it is probably not a good medication for you. It may be better to stop the medication or reduce the dosage.

@sue417
If you are feeling up and down each day, I believe that is normal while your brain/body adjusts to the new medication. Your 25 mg dosage is very low so it would be good to see how you are doing after 3-4 weeks. It sounds like you are not necessarily getting really bad side effects so far so you may want to give it more time.

Your doctor will want to see how you are doing after 1-2 months and then determine if they think increasing the dosage would be good or if adding a new medication combination would be better based upon your symptoms (like adding Wellbutrin).

Counseling and self care is so important for you now. Take good care of and advocate for yourself. You have been through so much with the loss of loved ones and breast cancer. You are a fighter and I am rooting for you❣️