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Tymlos side effects I've encountered
Osteoporosis & Bone Health | Last Active: Apr 7 12:28pm | Replies (401)Comment receiving replies
@lhankins that's awful! What did you end up taking afterwards?
I recall there was a study conducted for abaloparatide (Tymlos) with different doses 20mcg, 40mcg, and 80mcg (for 6mo only and a small study though). Although 80mcg showed best bmd increase, lower doses were not 100% ineffective - results showed a dose-dependent fashion.
While users of Tymlos should strive for the the marketed dose 80mcg to achieve maximal therapy results, dose titration upwards at the beginning of the therapy for those who experience severe adverse effects proved to be a great way to get 'accustomed' to Tymlos. Many members here at Connect had done so - @windyshores had many posts describing the method.
Replies to "@lhankins that's awful! What did you end up taking afterwards? I recall there was a study..."
Yes, that was the first trial of Tymlos. They found that 40 mcg helped the spine after 6 months, but did not help the hips. I took 40 mcg for 9 months. My spine went from -3.3 to -2.8 and there was no change in my hips.
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@mayblin
I was on the 0.8 (total clicks) for several months and then developed hypercalcemia and my rheumatologist took me off. He would not consider Evenity either since he said I would probably not tolerate that well either. He gave me the option of Prolia and I declined for the time being. I am in a point of limbo until I can see an endocrinologist. My appt is not until January 2026. I’m doing my best with nutrition, exercise and supplements until then. Crossing my fingers I will get a better treatment plan in 2026 and not having any fractures between now and then.