@sue417
I had been on Wellbutrin/bupropion and Zoloft/sertraline in the past at different times but never had them combined together.

In 2023, I had gradually weaned off the Wellbutrin and Cymbalta (treats nerve and osteoarthritis pain and depression) combination before having breast explant surgery (had breast implant illness symptoms and the saline plants ruptured) to see how I felt after surgery. My breast implant illness symptoms improved (did not have implants put back in) but I then lost my job, felt significant perimenopause/menopause symptoms, was dealing with chronic pain due to spinal stenosis/degenerative disc disease and became extremely depressed. I never felt this bad in my life. I had postpartum depression after having my son but never experienced crippling depression where I could not get out of bed or off the couch to do anything. I was always so productive and hard working and seemed to only be 5%-10% of my former self. Very scary for me because I am a single parent of a teenager and his sole provider (have no family).

My primary doctor the. put me on Prozac/fluoxetine 20 mg then increased to 40 mg but then I started getting brain zaps so stopped this medication. She then put me on Wellbutrin and it helped a little but not enough. She added Ativan but that caused bad side effects (pain/walking difficulty). She then tried mirtazapine but this made me want to eat everything around me so I stopped that. Finally, I started working with a psychiatrist to manage my depression medications and I asked him about the Zoloft/sertraline combination with Wellbutrin. He agreed to try it and first put me on 25 mg then 50 mg and now on 75 mg Zoloft/sertraline with 300 mg Wellbutrin (was first started on 75 mg 2x per day). My psychiatrist told me people say this combination makes them feel “well-oft” and I can say this is the only combination that seems to be helping me now. I am still only about 50% my former self but a lot is tied to my spine/spinal cord issues and chronic pain/physical limitations. I can at least get out of bed and off the couch to get some things done. It is good to feel a little more productive and hopeful again.

I am taking one day at a time. It would be great to have more energy to do more things. I may ask my psychiatrist if I should reduce my Zoloft/sertraline from 75 mg to 50 mg and Wellbutrin/bupropion from 300 mg to 150 mg to see if this would help reduce my fatigue.

Definitely talk to your doctor to see if Wellbutrin would be a good option for you.

May God bless you on your journey.