Something I found

The long-term benefits of using metformin alongside androgen deprivation therapy (ADT) are primarily related to its impact on metabolic health rather than overall survival:
• Metabolic Improvements: Metformin has consistently demonstrated significant benefits in reducing weight gain, glucose levels, and cholesterol profiles in patients undergoing ADT, potentially lowering the risk of cardiovascular complications. These effects were observed over extended periods, such as 24 months in the STAMPEDE trial.
• Mortality Reduction in Specific Cases: In diabetic prostate cancer patients, metformin use alongside ADT was associated with lower prostate cancer-related and all-cause mortality, suggesting potential benefits in specific populations.
• No Clear Overall Survival Benefit: Despite metabolic improvements, studies like the STAMPEDE trial found no significant increase in overall survival for unselected patients receiving metformin with ADT. However, hints of benefit were noted in subgroups with high-volume disease