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Rising psa 15 years after radiation: Is cancer back?

Prostate Cancer | Last Active: 4 days ago | Replies (26)
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@heavyphil

I think @bens1 contact person said that it can be used in salvage cases as well, but again, that’s a company rep touting his product.
Would love to see an actual study but the results would probably be a few years off anyway.

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Replies to "I think @bens1 contact person said that it can be used in salvage cases as well,..."
northoftheborder | @northoftheborder | Mar 31 11:33am

Exactly. I'm not saying it's wrong; just that it's unvalidated (sort-of an inside tip that might or might not pan out after peer review).

We do know (I think) that PSE is mainly for reducing false positives: that is, it won't make the PSA test more sensitive for actually finding a problem, but it can help us filter out false alarms.

So if you've had a prostatectomy or radiation at some point in the past and your PSA is undetectable or stable, as far as I understand, PSE would add no benefit; but if your PSA has suddenly changed from (say) 0.2 to 1.5 over the past year, PSE might add some extra info to help you and your oncology team decide whether you need to do anything about it yet (again, not sure if this use has been peer-reviewed yet).

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