Alternative dosing regimen for exemestane
https://jamanetwork.com/journals/jamaoncology/fullarticle/2802824 NB: although estrogen was lowered, study did not look at tumor outcomes, e.g. metastases, local recurrences, etc. on alternative dosing. In other words, the higher dose may be doing more than just lowering estrogen--and whatever that "more" is, is what's preventing the cancer from coming back. BTW, I'm neither an MD nor a scientist.

Alternative dosing regimen for letrozole
https://pubmed.ncbi.nlm.nih.gov/26667449/ Same caveat as exemestane study.

Alternative dosing regimen for tamoxifen
https://pmc.ncbi.nlm.nih.gov/articles/PMC11101371/ Not sure if tumor recurrence was the same as with full dose.

I've never found an equivalent study for anastrozole

Also, if I have misunderstood any these studies, please correct me!