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@jc76

@heavyphil
Agree Phil.
I am unfamiliar with the PSE. It sounds like a new and more precise test to determine if prostate cancer cells are outside of prostate. How new is it?

My R/O a UFHPTI wanted a PSMA done prior to final treatments plan. When I had my original consultation with Mayo they did not mention the PSMA to me just wanted Decipher and bone scan done.

I wonder if doing both a bone scan and a PSE is needed? Would a PSE show prostate cancer in bones and thus not need a bone scan? I will ask my R/O and PCP this as I am curious.

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Replies to "@heavyphil Agree Phil. I am unfamiliar with the PSE. It sounds like a new and more..."

Yes, JC, it’s fairly new but supposedly it is 94% accurate for detection of cancer - even if you’ve already been treated for PCa. Think it’s made by EpiSwitch?

PSE is a patented technique that combines PSA with an extra epigenetic test, so far mainly for routine screening of people who *haven't* been diagnosed with prostate cancer yet.

It's still the same old PSA test at the core, but the company that promotes it has shown evidence that adding some epigenetic tests reduces the number of false positives for screening the general population (e.g. people who haven't been diagnosed with prostate cancer) — in other words, if someone comes back with a borderline PSA result, the "E" part (epigenetic) might be able to rule out the need for an MRI and biopsy, at least at that time.

They've claimed it's helpful in other situations as well, but I don't know if they've published any peer-reviewed studies to back that up yet.