Wow thanks for your excellent comments! I love to hear how your wife has made it these many years. Bruce is now going on year 6. Lots of ups and downs and then the aging issues that come with being 81 as well. He did get an ulcer at one point but no one could give us a reason, we just figured the body was just fighting for itself and not succeeding. Fortunately, we did an experiment. We tracked all of his calcium, protein and iron intake and he had been getting far over the MDR. In studying absorption I ultimately learned that all three want an acid stomach. We were started on the PPI with the theory that I stated in my comment we hadn't heard what you stated above! {Good information!.] So to get his iron into the normal range, we tried giving him iron about midnight thinking the stomach maybe more acid then. But it didn't help, a little more study and I found that he since surgery lacked a transporter from the pancreas to the liver. So Oncology confirmed that and started him on Ferritin IV therapy when warranted. Made such a difference. Then from continued study, I found that the calcium and protein needed the acid as well. He drinks Ripple Milk, pea protein, which is highly absorbable with very little fat to cause gas. 8oz has 440 mg of calcium and 8 g of Protein. So for this month long experiment - he woke up about 6:30 a.m, and had 8 oz Ripple with Creon and NO proton-pump inhibitor. Then sleep for a while longer and then have PPI 30 minutes before breakfast. After a month and after getting routine lab work done, hadan appt with the pancreatic internist to discuss our concerns about calcium/protein absorption (hubby had 4 vertebrae compressions fractures that fall before we did the experiment. ) . For the first time in 5 years since the pan. surgery his Calcium was up in the normal range and his protein and albumin at last were as well!! The MD, smiled and said no when we asked if we really needed to take the omniproazole or could we work a system to enhance absorption and continue to take it. He said for one thing elderly people have alkaline stomachs more commonly than acid, and also that the Creon now had a hard enough shell to pass through the stomach to the intestine uninterrupted. So wonderful to learn this!! So he has begun gaining back more energy now. What you said about the ulcer formation is so important as they have wondered why he has a bit of bump formed at the stomach outlet, maybe where an ulcer was early on. Clearly we should be watching for a problem here, as he is also on Eliquis so bleeding can happen easily. Your message is so timely in alerting me to any possiblity of issues. Yes, we are enjoying the for thought of President Biden, also his impetus on cancer care research and dealing with the funds, as 2000 quickly leaves our pocket book in a month or so into each new year. Praise God, 3 years ago, the DNA evaluation of my husband's tumors was done. He had metasized to the adrenals 6 mo after surgery, but the chemo just was n't working . The lead Gastric Oncologist found that immunotherapy Keytruda could treat the situation. Which is unusual for pancreatic cancer and hubby had 2 tumors on his pancreas. Well the keytruda zapped it out of his body as far as they could tell on the next 3 month CT scan. ( we know pan. cancer can hide. ) He contined the therapy up to the 2 year limit of it, and did stop due to a side effect which has gone into remission now. I appreciate so much talking to another spouse of a heroic cancer patient. Would love to correspond more about your journey. Bruce also said he is so happy for you folks. The surgeon said at the beginning that my husband would be taking the PPI likely always. Hopefully hubby isn't in any real danger, So did you have absorption problems?