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ADT. Afraid of it

Prostate Cancer | Last Active: 1 day ago | Replies (67)

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@smc24

In reference to seasuite:
If you are on this Mayo Clinic chat, I assume you have prostate cancer. Typically, you would be highly advised to avoid testosterone boosting drugs at ALL cost. Testosterone is the primary food source for prostate cancer. You will note, most of the drugs taken for various stages of this disease are to eliminate as much testosterone as possible, including the need for a radical orchiectomy. My urologist had me on Androgel while my PSA was rising several years ago. It was like splashing gasoline on a smoldering fire. That fire became an inferno, which I'm now still dealing with today with a specialized cancer oncologist. Get another medical opinion.

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Replies to "In reference to seasuite: If you are on this Mayo Clinic chat, I assume you have..."

I understand your concern about testosterone and this was the prevailing opinion several years ago. But, thinking regarding TRT and prostate cancer is changing.

I was diagnosed with G9 prostate cancer in 2021 at age 68. Had RP with subsequent development of oligo metastatic disease treated with SBRT, triple therapy and whole pelvic radiation. I was on Lupron for only a year. My PSA became undetectable after second chemo/taxotere cycle and has remained so for >2 years. My T never rebounded after discontinuing the Lupron. I had the usual side effects related to low T.

Around 5 months ago my MO said he wanted to put me on TRT under the guidance of an endocrinologist. My MO is very experienced and has been treating prostate cancer for decades. He is at Johns Hopkins and is the Director of the Brady Urologic Prostate Cancer Research Center. He has published >500 articles on various topics related to prostate cancer. I trust his judgement completely.

Taking TRT is an individual decision between the patient and their physician. There are pros and cons, like everything in life. Medical decisions are about weighing risk vs reward. But to say patients with a history of prostate cancer (even metastatic) should never be put on TRT is incorrect.

Sorry to hear of your issues with Androgel.
If you take a look at my earlier post, I researched the topic for several months before proceeding with TRT, including consultations with multiple ROs and Urologists. Indeed, we are all very different and the conclusion was that, in my case, TRT that was caused by ADT (4 months), was an effective way to treat my slow recovery (more than one year) from Orgovyx. I also indicated that my PSA/T are tested quarterly and reviewed by my doctors. Additionally, the fertility specialist urologist also ordered:
ESTRADIOL, ULTRASENSITIVE, TESTOSTERONE, FREE & TOTAL, IMMUNOASSAY, COMPREHENSIVE METABOLIC PANEL (BMP, AST, ALT, T.BILI, ALKP, TP ALB); LIPID PANEL (INCL. LDL, HDL, TOTAL CHOL. AND TRIG.), HEMOCRIT