Hi, don't be discouraged it takes time and everyone is different. I am 78 years old and finally a year ago was negative but I was on the big 3 for over 2 years. After 9 mos I had to stop Ethambutal because of eye problems but continued Rifampin and Azithromycin. Then they put me on Aricayse (sp) but after 6 months had to get off because of a constant chronic cough. It is a long process but if you keep going it can be beat. I still worry everyday that it will come back but am glad for my days free of the many antibiotics. Good Luck