I have genetically high cholesterol but have been able to control mine for the most part with red yeast rice with CoQ10. It used to control my LDL and triglycerides beautifully but the FDA made them take out the strongest ingredient and now it does not work as well as it used to. I have tried bergamot for a year and had the worst total cholesterol, LDL and triglycerides of my life so I won't use that again but everyone's bodies are different. I am now experimenting with berberine to see if that helps. I am also pre-diabetic and berberine does lower my A1C a little bit.