I tapered off the last 37.5 over the course of a few weeks. You all are going to say "don't do that!" And, I'm like, "I feel fine!" One thing that happens when I'm on anti-depressants is I can drink alcohol and not get drunk or have hangovers. I'm still experiencing that... (I know, don't drink, working on it, again). I might be off Effexor, but my brain is not back to normal, as others have expressed on this list. I think it can take months for that to happen, which is super scary. The last time I went off an anti-depressant (Paxil) I relapsed horribly. But, I had big stressors at that time. My friend, a counselor and academic wellness center director, says find another med you can tolerate with fewer side effects, now, before you relapse again. My psychiatrist, a resident at a regional hospital, doesn't necessarily recommend that but went through some options with me. None sounded great. I wish I never, ever got on the stuff. I think when you're hit with depression you need to bow out of life and recover, like having TB before antibiotics. These drugs are just making it worse. Argh.