I started slowly with a .025 transdermal estradiol patch for 3 months, then .375 for 3 months, and then .05 which I'll stay on. With each new dose, I had breast tenderness. It wasn't bothersome and went away in a short amount of time. I tried 100 mg of oral Progesterone for sleep improvement but alas it didn't happen. I would say my mood was more mellow. I stopped taking it since I don't have a uterus. You can get DHEA with a prescription or over the counter. My systemic DHEA cream is a compounded prescription. There is an excellent local Rx vaginal DHEA but it's expensive, "Intrarosa". Amazon sells a vaginal DHEA "Bezwecken" that doesn't need a prescription. My next Dexa won't be until 2026 so I won't know for sure about my bone health but I'm confident that my numbers will stay in osteopenia (or better?). Try to be knowledgeable about HRT before you see your endocrinologist so you can advocate for yourself.