Tymlos comes in a pre-loaded pen with 30 doses; you administer one dose everyday. The prescribed dose is 80 mcg, and you set the dose by turning a knob from 0 to 80. The knob is ratcheted in 10 mcg increments, so as you turn it you hear a click at each 10 mcgs. So, 80 is 8 clicks. Folks who find the full dose to be too strong or to have too many unpleasant side effects often lower their dose by just dialing to a lower number, ie a lower number of clicks, from 1 to 8.

If you go to tymlos.com you can find the warnings and contraindications. I don't recall heart problems being one of them, but I wouldn't have paid attention to that one myself. My concern was cancer risks, but they state that cancer was found only in lab rats, not in humans, so.....