Hello, @ghmcgran - welcome to Mayo Clinic Connect. Sounds like you have been around the block a bit with various selective serotonin reuptake inhibitors (SSRIs) https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825.

Have you had experience taking venlafaxine (Effexor) and tapering off of it? If so, how did that go?