@kh4976 My slides for endometrial cancer (not breast cancer) were first read at my local hospital. The diagnosis of endometroid adenocarcinoma was diagnosed with FIGO Grade 2. Since I was referred to Mayo Clinic my surgeon at Mayo requested that my slides be sent to Mayo Clinic to be read by their pathologists. Same diagnosis of endometroid adenocarcinoma but Mayo Clinic pathologists diagnosed FIGO Grade 1. Did this change the treatment? No, I still had a radical hysterectomy with fallopian tubes, ovaries, and cervix all removed. However, FIGO Grade 2 indicates that the cells are more organized into a tumor than FIGO Grade 1 which could mean that the cancer was more advanced.

My husband is a pathologist (now retired). He says that this sort of disagreement on diagnoses can occur and when that happens it's best to get the pathologists to talk with one another and get another opinion. That's what you did. Have you found out anything else?