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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Mar 24 11:26am | Replies (214)Comment receiving replies
Thank you @mayblin for your insights! I, too, think perhaps the 112 P1NP is my spike and that gives me hope that Tymlos is working. The CTX was at 79 when in Oct 23 I was due for my Prolia and decided to stop, so it had been 6 months since my last one. It was only the second time it had ever been checked during my time on Prolia, and I have no actual starting baseline with that either!
Do you think at my next labs the CTX should show even lower? I am thinking that would be good. Will be repeating in 2-3 months. Hopefully by then I will have found a better healthcare professional to quarterback this disease with me. Thank you for caring, can you tell me a bit more about your being on estradiol?
Replies to "Thank you @mayblin for your insights! I, too, think perhaps the 112 P1NP is my spike..."
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I see. I was thinking if you had CTX monitored regularly during Boniva, they might've given you a clue as to if Boniva is adequate in keeping rebound in check.
Your plan of repeating bone marker labs sounds great! Either a decrease in CTX or increase in P1NP or both is a step toward the right direction. CTX is unpredictable at this stage in my view because of the combined effects of prolia cessation and Tymlos.
The main purpose of my estradiol use is for its antiresorptive effect - as a followup after Forteo. Thanks for asking. There are 3 dosages for estradiol patches named:
Ultra low dose: 0.014mg/day
Low dose: 0.025mg/day
'Regular or standard' dose: 0.05mg/day
The dose of 0.0375mg/day is also available, so are higher doses greater than 0.05mg/day.
Many endos use standard dose for bone effects. However low dose was studied also and appeared to be effective but might be dependent on age and other factors. I elected low dose to start with monitoring bone markers, considering that my frax score is fairly low. Turns out this dose worked very well for me: CTX went down to 163 and dxa had further improvements after 6mo estradiol. Without a baseline bone markers prior to treatments, monitoring btm periodically to see the trend is useful in my case.