Sadly, many on here can attest that many doctors do not know how to taper someone off Effexor. Trying to taper by skipping days means that the levels of Effexor in your body will yo yo dramatically; this drug has a very short half-life already which makes it hard to get off of. You'd do better to reduce the amount of drug you take at each dosing. You reduce by a small amount, stay there for weeks, or months until you aren't experiencing withdrawal effects and then make another small step down.