I think that we all suffered some adrenal insufficiency. Anything past 2 weeks the body quits producing cortisol. But as it pertains to your question , that would be your body failing to restart. From what I have read and others comments the length of time on steroids is largely responsible. I think if your body really does not restart it would be very difficult to function. This would then be diagnosed as Addison's disease. Addisons is considered very rare. Dadcue was on a twelve year battle but eventually restarted with the help of Actemra. It would be interesting to know if there are those that there body fails to restart. Most of the comments I see are those that find it much easier to stay on low dose than actually cant restart.